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[DOI] [PubMed] [Google Scholar] Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S (2015) Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

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One investigation indicated that estrogen enhances C3 secretion in rat uterine epithelium, a phenomenon not replicated in the liver (82), suggesting that the effects of estrogen may be tissue-specific and cannot be generalized as universally activating the complement system